Python
late 16th century (in the Greek sense): via Latin from Greek Puthōn, the name of a huge serpent killed by Apollo. The main current sense dates from the mid 19th century.
wiktionary
Latin pȳthon, from Ancient Greek Πύθων(Púthōn), the name of the mythological enormous serpent at Delphi slain by Apollo, probably from Πυθώ(Puthṓ), older name of Delphi.
etymonline
python (n.)
1580s, name of a fabled serpent, slain by Apollo near Delphi, from Latin Python, from Greek Pythōn "serpent slain by Apollo," probably related to Pythō, the old name of Delphi. Chaucer has it (late 14c.) as Phitoun.
This might be related to pythein "to rot," or from PIE *dhubh-(o)n-, from *dheub- "hollow, deep, bottom, depths," and used in reference to the monsters who inhabit them. Loosely used for "any very large snake," hence the zoological application to large non-venomous snakes of the tropics (1836, originally in French). Related: Pythonic.