Disease

google

ref

Middle English (in the sense ‘lack of ease; inconvenience’): from Old French desaise ‘lack of ease’, from des- (expressing reversal) + aise ‘ease’.

wiktionary

ref

From Middle English disese, from Anglo-Norman desese, disaise, from Old French desaise, from des- + aise. Equivalent to dis- +‎ ease. Displaced native Middle English adle, audle(“disease”) (from Old English ādl(“disease, sickness”), see adle), Middle English cothe, coathe(“disease”) (from Old English coþu(“disease”), see coath).

etymonline

ref

disease (n.)

early 14c., "discomfort, inconvenience, distress, trouble," from Old French desaise "lack, want; discomfort, distress; trouble, misfortune; disease, sickness," from des- "without, away" (see dis-) + aise "ease" (see ease (n.)). Restricted pathological sense of "sickness, illness" in English emerged by late 14c.; the word still sometimes was used in its literal sense early 17c., and was somewhat revived 20c., usually with a hyphen (dis-ease).

disease (v.)

mid-14c., disesen, "to make uneasy, trouble; inflict pain," a sense now obsolete; late 14c. as "to have an illness or infection;" late 15c. in the transitive sense of "to infect with a disease, make ill;" from disease (n.). Tyndale (1526) has Thy doughter is deed, disease not the master where KJV has trouble not (Luke viii.49).