Anesthesia
early 18th century: modern Latin, from Greek anaisthēsia, from an- ‘without’ + aisthēsis ‘sensation’.
wiktionary
an- + aesthesia, from Ancient Greek ἀναισθησία(anaisthēsía), from ἀν-(an-, “not”) with αἴσθησις(aísthēsis, “sensation”).
Coined in 1846 C.E. by Oliver Wendell Holmes, Sr., in a letter to dentist William T. G. Morton, the first practitioner to publicly demonstrate the use of ether during surgery, writing:
etymonline
anesthesia (n.)
1721, "loss of feeling," medical Latin, from Greek anaisthēsia "want of feeling or perception, lack of sensation (to pleasure or pain)," abstract noun from an- "without" (see an- (1)) + aisthēsis "feeling," from PIE root *au- "to perceive." For the abstract noun ending, see -ia. As "a procedure for the prevention of pain in surgical operations," from 1846. Aesthesia "capacity for feeling" is attested in English from 1853, perhaps a back-formation.