Sac
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mid 18th century (as a term in biology): from French sac or Latin saccus ‘sack, bag’.
wiktionary
Borrowed from French sac. Doublet of sack.
Clipping of sacrifice.
See sake, soc.
etymonline
sac (n.)
"biological pocket or receptacle," 1741, from French sac, from Latin saccus "bag" (see sack (n.1)). English sack for "a sack-like part of the body" is from mid-14c.
Sac
central Algonquian people who lived near the upper Mississippi before the 1832 Black Hawk War, from French Canadian Saki, probably a shortened borrowing of Ojibwa (Algonquian) /osa:ki:/, literally "person of the outlet" (of the Saginaw River, which itself contains their name, and means literally "in the Sac country").